Assay Detail
Binding
CHEMBL812000
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Ability to inhibit human telomerase in a modified cell-free TRAP assay using extracts from A2780 cell line
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | A2780 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Human telomerase inhibition by substituted acridine derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 5.40 | 5.87 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL309919 | — | — | 1 | 5.87 |
| CHEMBL431404 | — | — | 1 | 5.58 |
| CHEMBL81747 | — | — | 1 | 5.57 |
| CHEMBL81268 | — | — | 1 | 5.55 |
| CHEMBL82008 | — | — | 1 | 5.51 |
| CHEMBL311055 | — | — | 1 | 5.39 |
| CHEMBL83173 | — | — | 1 | 5.36 |
| CHEMBL79900 | — | — | 1 | 5.28 |
| CHEMBL81271 | — | — | 1 | 5.27 |
| CHEMBL309982 | — | — | 1 | 5.24 |
| CHEMBL81516 | — | — | 1 | 5.10 |
| CHEMBL311072 | — | — | 1 | 5.09 |
| CHEMBL79536 | — | — | 1 | - |
| CHEMBL421143 | — | — | 1 | - |
| CHEMBL310569 | — | — | 1 | - |
| CHEMBL310838 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL309919 | — | IC50 | = | 1350.0 | nM | 5.87 |
| CHEMBL431404 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL81747 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL81268 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL82008 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL311055 | — | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL83173 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL79900 | — | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL81271 | — | IC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL309982 | — | IC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL81516 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL311072 | — | IC50 | = | 8200.0 | nM | 5.09 |
| CHEMBL79536 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL421143 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL310569 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL310838 | — | IC50 | > | 50000.0 | nM | - |