Assay Detail
Binding
CHEMBL812057
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In vitro evaluation for inhibitor of human topoisomerase II from HeLa cells.
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | HeLa |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Synthesis and antitumor activity of 4-aminomethylthioxanthenone and 5-aminomethylbenzothiopyranoindazole derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 23 | 5.51 | 6.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL27233 | — | — | 1 | 6.48 |
| CHEMBL121666 | — | — | 1 | 6.30 |
| CHEMBL30104 | — | — | 1 | 6.26 |
| CHEMBL121442 | — | — | 1 | 5.80 |
| CHEMBL283395 | — | — | 1 | 5.52 |
| CHEMBL122716 | — | — | 1 | 5.00 |
| CHEMBL121192 | — | — | 1 | 4.70 |
| CHEMBL333026 | — | — | 1 | 4.05 |
| CHEMBL330996 | — | — | 1 | - |
| CHEMBL332805 | — | — | 1 | - |
| CHEMBL434812 | — | — | 1 | - |
| CHEMBL27064 | — | — | 1 | - |
| CHEMBL30099 | — | — | 1 | - |
| CHEMBL121547 | — | — | 1 | - |
| CHEMBL333641 | — | — | 1 | - |
| CHEMBL30053 | — | — | 1 | - |
| CHEMBL280609 | — | — | 1 | - |
| CHEMBL25908 | — | — | 1 | - |
| CHEMBL29836 | — | — | 1 | - |
| CHEMBL27542 | — | — | 1 | - |
| CHEMBL281022 | — | — | 1 | - |
| CHEMBL120915 | — | — | 1 | - |
| CHEMBL287205 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL27233 | — | EC50 | = | 330.0 | nM | 6.48 |
| CHEMBL121666 | — | EC50 | = | 500.0 | nM | 6.30 |
| CHEMBL30104 | — | EC50 | = | 550.0 | nM | 6.26 |
| CHEMBL121442 | — | EC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL283395 | — | EC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL122716 | — | EC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL121192 | — | EC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL333026 | — | EC50 | = | 90000.0 | nM | 4.05 |
| CHEMBL330996 | — | EC50 | > | 270000.0 | nM | - |
| CHEMBL332805 | — | EC50 | > | 500000.0 | nM | - |
| CHEMBL434812 | — | EC50 | > | 480000.0 | nM | - |
| CHEMBL27064 | — | EC50 | > | 260000.0 | nM | - |
| CHEMBL30099 | — | EC50 | > | 220000.0 | nM | - |
| CHEMBL121547 | — | EC50 | > | 210000.0 | nM | - |
| CHEMBL333641 | — | EC50 | > | 220000.0 | nM | - |
| CHEMBL30053 | — | EC50 | > | 210000.0 | nM | - |
| CHEMBL280609 | — | EC50 | > | 240000.0 | nM | - |
| CHEMBL25908 | — | EC50 | > | 230000.0 | nM | - |
| CHEMBL29836 | — | EC50 | > | 220000.0 | nM | - |
| CHEMBL27542 | — | EC50 | > | 240000.0 | nM | - |
| CHEMBL281022 | — | EC50 | > | 250000.0 | nM | - |
| CHEMBL120915 | — | EC50 | = | 510000.0 | nM | - |
| CHEMBL287205 | — | EC50 | > | 260000.0 | nM | - |