Assay Detail
Binding
CHEMBL812171
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Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1
26
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
4,4-Disubstituted cyclohexylamine NK(1) receptor antagonists I.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 26 | 8.30 | 9.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL296583 | — | — | 1 | 9.54 |
| CHEMBL2115007 | — | — | 1 | 9.47 |
| CHEMBL49176 | — | — | 3 | 9.46 |
| CHEMBL50867 | — | — | 1 | 9.36 |
| CHEMBL300014 | — | — | 1 | 9.31 |
| CHEMBL295685 | — | — | 1 | 9.21 |
| CHEMBL296397 | — | — | 1 | 9.20 |
| CHEMBL2115006 | — | — | 1 | 9.15 |
| CHEMBL51417 | — | — | 1 | 9.12 |
| CHEMBL422931 | — | — | 1 | 9.02 |
| CHEMBL2115005 | — | — | 1 | 8.77 |
| CHEMBL2115004 | — | — | 1 | 8.60 |
| CHEMBL2115010 | — | — | 1 | 8.38 |
| CHEMBL296629 | — | — | 1 | 8.28 |
| CHEMBL2115008 | — | — | 1 | 8.20 |
| CHEMBL49175 | — | — | 1 | 7.40 |
| CHEMBL2115454 | — | — | 1 | 7.23 |
| CHEMBL2115450 | — | — | 1 | 7.09 |
| CHEMBL2115451 | — | — | 1 | 7.07 |
| CHEMBL2115009 | — | — | 1 | 6.92 |
| CHEMBL46103 | — | — | 1 | 6.89 |
| CHEMBL2115449 | — | — | 1 | 6.85 |
| CHEMBL51893 | — | — | 1 | 6.82 |
| CHEMBL2115452 | — | — | 1 | 6.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL296583 | — | IC50 | = | 0.29 | nM | 9.54 |
| CHEMBL2115007 | — | IC50 | = | 0.34 | nM | 9.47 |
| CHEMBL49176 | — | IC50 | = | 0.35 | nM | 9.46 |
| CHEMBL50867 | — | IC50 | = | 0.44 | nM | 9.36 |
| CHEMBL300014 | — | IC50 | = | 0.49 | nM | 9.31 |
| CHEMBL295685 | — | IC50 | = | 0.62 | nM | 9.21 |
| CHEMBL296397 | — | IC50 | = | 0.63 | nM | 9.20 |
| CHEMBL2115006 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL51417 | — | IC50 | = | 0.75 | nM | 9.12 |
| CHEMBL49176 | — | IC50 | = | 0.77 | nM | 9.11 |
| CHEMBL422931 | — | IC50 | = | 0.95 | nM | 9.02 |
| CHEMBL49176 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL2115005 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL2115004 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL2115010 | — | IC50 | = | 4.2 | nM | 8.38 |
| CHEMBL296629 | — | IC50 | = | 5.3 | nM | 8.28 |
| CHEMBL2115008 | — | IC50 | = | 6.3 | nM | 8.20 |
| CHEMBL49175 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL2115454 | — | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL2115450 | — | IC50 | = | 82.0 | nM | 7.09 |
| CHEMBL2115451 | — | IC50 | = | 85.0 | nM | 7.07 |
| CHEMBL2115009 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL46103 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL2115449 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL51893 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL2115452 | — | IC50 | = | 250.0 | nM | 6.60 |