Assay Detail
Binding
CHEMBL812282
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Compound was tested for topoisomerase II inhibition in purified HeLa cells by SDS/K+ precipitation method
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | HeLa |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
The antitumor activity of novel pyrazoloquinoline derivatives
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 23 | 5.47 | 6.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL132098 | — | — | 1 | 6.30 |
| CHEMBL43 | AMSACRINE | 4.0 | 1 | 6.14 |
| CHEMBL44657 | ETOPOSIDE | 4.0 | 1 | 6.09 |
| CHEMBL130627 | — | — | 1 | 6.05 |
| CHEMBL336549 | — | — | 1 | 5.77 |
| CHEMBL131677 | — | — | 1 | 5.77 |
| CHEMBL421899 | — | — | 1 | 5.77 |
| CHEMBL130381 | — | — | 1 | 5.58 |
| CHEMBL335683 | — | — | 1 | 5.57 |
| CHEMBL131600 | — | — | 1 | 5.51 |
| CHEMBL129908 | — | — | 1 | 5.50 |
| CHEMBL133802 | — | — | 1 | 5.48 |
| CHEMBL445908 | — | — | 1 | 5.38 |
| CHEMBL131262 | — | — | 1 | 5.36 |
| CHEMBL133466 | — | — | 1 | 5.23 |
| CHEMBL133784 | — | — | 1 | 5.21 |
| CHEMBL133757 | — | — | 1 | 5.19 |
| CHEMBL130332 | — | — | 1 | 5.13 |
| CHEMBL8179 | WIN-57294 | — | 1 | 5.12 |
| CHEMBL337180 | — | — | 1 | 5.01 |
| CHEMBL334386 | — | — | 1 | 5.00 |
| CHEMBL131491 | — | — | 1 | 4.96 |
| CHEMBL414022 | — | — | 1 | 4.77 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL132098 | — | EC50 | = | 500.0 | nM | 6.30 |
| CHEMBL43 | AMSACRINE | EC50 | = | 720.0 | nM | 6.14 |
| CHEMBL44657 | ETOPOSIDE | EC50 | = | 810.0 | nM | 6.09 |
| CHEMBL130627 | — | EC50 | = | 900.0 | nM | 6.05 |
| CHEMBL336549 | — | EC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL131677 | — | EC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL421899 | — | EC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL130381 | — | EC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL335683 | — | EC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL131600 | — | EC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL129908 | — | EC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL133802 | — | EC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL445908 | — | EC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL131262 | — | EC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL133466 | — | EC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL133784 | — | EC50 | = | 6100.0 | nM | 5.21 |
| CHEMBL133757 | — | EC50 | = | 6400.0 | nM | 5.19 |
| CHEMBL130332 | — | EC50 | = | 7400.0 | nM | 5.13 |
| CHEMBL8179 | WIN-57294 | EC50 | = | 7600.0 | nM | 5.12 |
| CHEMBL337180 | — | EC50 | = | 9800.0 | nM | 5.01 |
| CHEMBL334386 | — | EC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL131491 | — | EC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL414022 | — | EC50 | = | 17000.0 | nM | 4.77 |