Assay Detail
Binding
CHEMBL812283
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Inhibitory activity against HeLa cell Topoisomerase II
36
Total Activities
36
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | HeLa |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
3-benzyl-quinolones: Novel, potent inhibitors of mammalian topoisomerase II
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 36 | 5.73 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL8 | CIPROFLOXACIN | 4.0 | 1 | 7.52 |
| CHEMBL440642 | — | — | 1 | 7.02 |
| CHEMBL428339 | — | — | 1 | 7.01 |
| CHEMBL269139 | — | — | 1 | 6.80 |
| CHEMBL7877 | — | — | 1 | 6.80 |
| CHEMBL268458 | — | — | 1 | 6.48 |
| CHEMBL7690 | — | — | 1 | 6.44 |
| CHEMBL43 | AMSACRINE | 4.0 | 1 | 6.14 |
| CHEMBL44657 | ETOPOSIDE | 4.0 | 1 | 6.09 |
| CHEMBL7960 | — | — | 1 | 5.96 |
| CHEMBL8063 | — | — | 1 | 5.96 |
| CHEMBL7534 | — | — | 1 | 5.92 |
| CHEMBL267251 | — | — | 1 | 5.80 |
| CHEMBL7769 | — | — | 1 | 5.68 |
| CHEMBL7562 | — | — | 1 | 5.48 |
| CHEMBL8161 | — | — | 1 | 5.41 |
| CHEMBL267707 | — | — | 1 | 5.33 |
| CHEMBL7618 | — | — | 1 | 5.29 |
| CHEMBL7368 | — | — | 1 | 5.29 |
| CHEMBL8138 | — | — | 1 | 5.17 |
| CHEMBL7564 | — | — | 1 | 5.14 |
| CHEMBL8179 | WIN-57294 | — | 1 | 5.12 |
| CHEMBL7848 | — | — | 1 | 5.11 |
| CHEMBL7216 | — | — | 1 | 5.04 |
| CHEMBL7794 | — | — | 1 | 4.92 |
| CHEMBL266463 | — | — | 1 | 4.85 |
| CHEMBL7831 | — | — | 1 | 4.85 |
| CHEMBL7972 | — | — | 1 | 4.85 |
| CHEMBL414022 | — | — | 1 | 4.77 |
| CHEMBL267017 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL8 | CIPROFLOXACIN | EC50 | = | 30.0 | nM | 7.52 |
| CHEMBL440642 | — | EC50 | = | 96.0 | nM | 7.02 |
| CHEMBL428339 | — | EC50 | = | 98.0 | nM | 7.01 |
| CHEMBL269139 | — | EC50 | = | 160.0 | nM | 6.80 |
| CHEMBL7877 | — | EC50 | = | 160.0 | nM | 6.80 |
| CHEMBL268458 | — | EC50 | = | 330.0 | nM | 6.48 |
| CHEMBL7690 | — | EC50 | = | 360.0 | nM | 6.44 |
| CHEMBL43 | AMSACRINE | EC50 | = | 720.0 | nM | 6.14 |
| CHEMBL44657 | ETOPOSIDE | EC50 | = | 810.0 | nM | 6.09 |
| CHEMBL7960 | — | EC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL8063 | — | EC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL7534 | — | EC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL267251 | — | EC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL7769 | — | EC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL7562 | — | EC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL8161 | — | EC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL267707 | — | EC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL7368 | — | EC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL7618 | — | EC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL8138 | — | EC50 | = | 6800.0 | nM | 5.17 |
| CHEMBL7564 | — | EC50 | = | 7200.0 | nM | 5.14 |
| CHEMBL8179 | WIN-57294 | EC50 | = | 7600.0 | nM | 5.12 |
| CHEMBL7848 | — | EC50 | = | 7700.0 | nM | 5.11 |
| CHEMBL7216 | — | EC50 | = | 9100.0 | nM | 5.04 |
| CHEMBL7794 | — | EC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL7972 | — | EC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL7831 | — | EC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL266463 | — | EC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL414022 | — | EC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL267017 | — | EC50 | > | 210000.0 | nM | - |
| CHEMBL7722 | — | EC50 | > | 230000.0 | nM | - |
| CHEMBL7392 | — | EC50 | = | 200000.0 | nM | - |
| CHEMBL7991 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL7704 | — | EC50 | > | 120000.0 | nM | - |
| CHEMBL7999 | — | EC50 | > | 120000.0 | nM | - |
| CHEMBL7689 | — | EC50 | > | 210000.0 | nM | - |