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Assay Detail

CHEMBL812385

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibitory potency against human stromelysin, MMP-3
33
Total Activities
33
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Stromelysin-1 (CHEMBL283)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Inhibition of matrix metalloproteinases by hydroxamates containing heteroatom-based modifications of the P1' group.
Gowravaram MR, Tomczuk BE, Johnson JS, Delecki D, Cook ER, Ghose AK, Mathiowetz AM, Spurlino JC, Rubin B, Smith DL.
J Med Chem (1995) 38 : 2570 -2581
PubMed 7629797 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 33 7.54 8.70

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL431408 1 8.70
CHEMBL313140 1 8.52
CHEMBL420786 1 8.30
CHEMBL87775 1 8.30
CHEMBL87113 1 8.22
CHEMBL315493 1 8.22
CHEMBL86797 1 8.22
CHEMBL421161 1 8.05
CHEMBL87460 1 7.96
CHEMBL87990 1 7.92
CHEMBL59023 1 7.85
CHEMBL419301 1 7.85
CHEMBL87229 1 7.82
CHEMBL313207 1 7.80
CHEMBL314251 1 7.77
CHEMBL85806 1 7.72
CHEMBL410259 1 7.55
CHEMBL406131 1 7.42
CHEMBL441455 1 7.39
CHEMBL313483 1 7.37
CHEMBL85987 1 7.27
CHEMBL314051 1 7.21
CHEMBL88302 1 7.19
CHEMBL11306 1 7.10
CHEMBL430838 1 7.04
CHEMBL431601 1 6.95
CHEMBL85766 1 6.44
CHEMBL87046 1 6.37
CHEMBL313356 1 6.16
CHEMBL86468 1 5.66

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL431408 Ki = 2.0 nM 8.70
CHEMBL313140 Ki = 3.0 nM 8.52
CHEMBL420786 Ki = 5.0 nM 8.30
CHEMBL87775 Ki = 5.0 nM 8.30
CHEMBL87113 Ki = 6.0 nM 8.22
CHEMBL315493 Ki = 6.0 nM 8.22
CHEMBL86797 Ki = 6.0 nM 8.22
CHEMBL421161 Ki = 9.0 nM 8.05
CHEMBL87460 Ki = 11.0 nM 7.96
CHEMBL87990 Ki = 12.0 nM 7.92
CHEMBL59023 Ki = 14.0 nM 7.85
CHEMBL419301 Ki = 14.0 nM 7.85
CHEMBL87229 Ki = 15.0 nM 7.82
CHEMBL313207 Ki = 16.0 nM 7.80
CHEMBL314251 Ki = 17.0 nM 7.77
CHEMBL85806 Ki = 19.0 nM 7.72
CHEMBL410259 Ki = 28.0 nM 7.55
CHEMBL406131 Ki = 38.0 nM 7.42
CHEMBL441455 Ki = 41.0 nM 7.39
CHEMBL313483 Ki = 43.0 nM 7.37
CHEMBL85987 Ki = 54.0 nM 7.27
CHEMBL314051 Ki = 62.0 nM 7.21
CHEMBL88302 Ki = 65.0 nM 7.19
CHEMBL11306 Ki = 79.0 nM 7.10
CHEMBL430838 Ki = 92.0 nM 7.04
CHEMBL431601 Ki = 112.0 nM 6.95
CHEMBL85766 Ki = 360.0 nM 6.44
CHEMBL87046 Ki = 430.0 nM 6.37
CHEMBL313356 Ki = 700.0 nM 6.16
CHEMBL86468 Ki = 2200.0 nM 5.66
CHEMBL85933 Ki > 10000.0 nM -
CHEMBL84576 Ki < 2.0 nM -
CHEMBL315688 Ki < 2.0 nM -