Assay Detail
Binding
CHEMBL812394
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Steroid 5-alpha-reductase type 2 from human benign prostatic hyperplasia (BPH) tissue
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
3-oxo-5-alpha-steroid 4-dehydrogenase 2 (CHEMBL1856) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis and evaluation of 2'-substituted 4-(4'-carboxy- or 4'-carboxymethylbenzylidene)-N-acylpiperidines: highly potent and in vivo active steroid 5alpha-reductase type 2 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 6.83 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL710 | FINASTERIDE | 4.0 | 1 | 8.30 |
| CHEMBL113726 | — | — | 1 | 8.22 |
| CHEMBL115438 | — | — | 1 | 8.15 |
| CHEMBL117793 | — | — | 1 | 7.96 |
| CHEMBL424066 | — | — | 1 | 7.22 |
| CHEMBL114948 | — | — | 1 | 6.89 |
| CHEMBL115123 | — | — | 1 | 6.68 |
| CHEMBL114114 | — | — | 1 | 6.58 |
| CHEMBL117881 | — | — | 1 | 6.39 |
| CHEMBL115019 | — | — | 1 | 6.37 |
| CHEMBL115298 | — | — | 1 | 6.28 |
| CHEMBL114594 | — | — | 1 | 6.08 |
| CHEMBL117643 | — | — | 1 | 5.96 |
| CHEMBL432641 | — | — | 1 | 5.92 |
| CHEMBL116621 | — | — | 1 | 5.46 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL710 | FINASTERIDE | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL113726 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL115438 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL117793 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL424066 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL114948 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL115123 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL114114 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL117881 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL115019 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL115298 | — | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL114594 | — | IC50 | = | 830.0 | nM | 6.08 |
| CHEMBL117643 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL432641 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL116621 | — | IC50 | = | 3500.0 | nM | 5.46 |