Assay Detail
Binding
CHEMBL812404
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was evaluated for the inhibition of human Steroid 5-alpha-reductase type 2
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
3-oxo-5-alpha-steroid 4-dehydrogenase 2 (CHEMBL1856) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis of benzo[c]quinolizin-3-ones: selective non-steroidal inhibitors of steroid 5 alpha-reductase 1.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 5.64 | 6.58 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL25081 | — | — | 1 | 6.58 |
| CHEMBL97266 | — | — | 1 | 4.70 |
| CHEMBL417109 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL25081 | — | Ki | = | 260.0 | nM | 6.58 |
| CHEMBL97266 | — | Ki | = | 20000.0 | nM | 4.70 |
| CHEMBL417109 | — | Ki | > | 1000.0 | nM | - |