Assay Detail
Binding
CHEMBL812405
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Apparent inhibition constant towards human Steroid 5-alpha-reductase type 2
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
3-oxo-5-alpha-steroid 4-dehydrogenase 2 (CHEMBL1856) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
A non-steroidal diene acid inhibitor of human type 2 stereoid 5-reductase
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 7.35 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL138225 | EPRISTERIDE | 2.0 | 1 | 9.70 |
| CHEMBL78060 | — | — | 1 | 9.10 |
| CHEMBL710 | FINASTERIDE | 4.0 | 1 | 8.70 |
| CHEMBL308806 | — | — | 1 | 6.58 |
| CHEMBL449649 | — | — | 1 | 5.80 |
| CHEMBL76998 | — | — | 1 | 5.80 |
| CHEMBL310915 | — | — | 1 | 5.80 |
| CHEMBL75294 | — | — | 1 | - |
| CHEMBL279417 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL138225 | EPRISTERIDE | Ki | = | 0.2 | nM | 9.70 |
| CHEMBL78060 | — | Ki | = | 0.8 | nM | 9.10 |
| CHEMBL710 | FINASTERIDE | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL308806 | — | Ki | = | 260.0 | nM | 6.58 |
| CHEMBL449649 | — | Ki | = | 1600.0 | nM | 5.80 |
| CHEMBL76998 | — | Ki | = | 1600.0 | nM | 5.80 |
| CHEMBL310915 | — | Ki | = | 1600.0 | nM | 5.80 |
| CHEMBL75294 | — | Ki | > | 2500.0 | nM | - |
| CHEMBL279417 | — | Ki | > | 5000.0 | nM | - |