Assay Detail
Functional
CHEMBL812474
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of TdR phosphorylation using thymidine kinase (TK) assay for herpes simplex virus type 2 (HSV-2).
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human alphaherpesvirus 2 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Thymidine kinase (CHEMBL1820) ↗| Type | SINGLE PROTEIN |
| Organism | Human herpesvirus 1 (strain SC16) (HHV-1) (Human herpes simplex virus1) |
Publication
Structure-activity relationships of N2-substituted guanines as inhibitors of HSV1 and HSV2 thymidine kinases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 2 | 5.93 | 6.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3143935 | — | — | 1 | 6.16 |
| CHEMBL3144572 | — | — | 1 | 5.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3143935 | — | Ki | = | 700.0 | nM | 6.16 |
| CHEMBL3144572 | — | Ki | = | 2000.0 | nM | 5.70 |