Assay Detail
Binding
CHEMBL812541
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance P
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CHO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Acyclic NK-1 antagonists: 2-benzhydryl-2-aminoethyl ethers
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 7.86 | 9.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL56038 | — | — | 1 | 9.28 |
| CHEMBL28055 | — | — | 1 | 9.07 |
| CHEMBL283356 | L-706125 | — | 1 | 9.00 |
| CHEMBL53901 | — | — | 1 | 8.66 |
| CHEMBL55823 | — | — | 1 | 8.36 |
| CHEMBL56427 | — | — | 1 | 8.26 |
| CHEMBL55476 | — | — | 1 | 8.17 |
| CHEMBL417784 | — | — | 1 | 8.03 |
| CHEMBL56372 | — | — | 1 | 8.01 |
| CHEMBL281940 | — | — | 1 | 7.97 |
| CHEMBL56442 | — | — | 1 | 7.96 |
| CHEMBL59380 | — | — | 1 | 7.95 |
| CHEMBL56814 | — | — | 1 | 7.90 |
| CHEMBL299275 | — | — | 1 | 7.88 |
| CHEMBL53846 | — | — | 1 | 7.85 |
| CHEMBL56811 | — | — | 1 | 7.77 |
| CHEMBL59310 | — | — | 1 | 7.68 |
| CHEMBL55796 | — | — | 1 | 7.26 |
| CHEMBL264376 | — | — | 1 | 7.12 |
| CHEMBL55635 | — | — | 1 | 7.11 |
| CHEMBL418114 | — | — | 1 | 7.09 |
| CHEMBL417766 | — | — | 1 | 7.03 |
| CHEMBL55651 | — | — | 1 | 6.82 |
| CHEMBL56176 | — | — | 1 | 6.43 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL56038 | — | IC50 | = | 0.53 | nM | 9.28 |
| CHEMBL28055 | — | IC50 | = | 0.85 | nM | 9.07 |
| CHEMBL283356 | L-706125 | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL53901 | — | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL55823 | — | IC50 | = | 4.4 | nM | 8.36 |
| CHEMBL56427 | — | IC50 | = | 5.5 | nM | 8.26 |
| CHEMBL55476 | — | IC50 | = | 6.8 | nM | 8.17 |
| CHEMBL417784 | — | IC50 | = | 9.3 | nM | 8.03 |
| CHEMBL56372 | — | IC50 | = | 9.7 | nM | 8.01 |
| CHEMBL281940 | — | IC50 | = | 10.7 | nM | 7.97 |
| CHEMBL56442 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL59380 | — | IC50 | = | 11.3 | nM | 7.95 |
| CHEMBL56814 | — | IC50 | = | 12.7 | nM | 7.90 |
| CHEMBL299275 | — | IC50 | = | 13.3 | nM | 7.88 |
| CHEMBL53846 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL56811 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL59310 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL55796 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL264376 | — | IC50 | = | 75.0 | nM | 7.12 |
| CHEMBL55635 | — | IC50 | = | 77.0 | nM | 7.11 |
| CHEMBL418114 | — | IC50 | = | 82.0 | nM | 7.09 |
| CHEMBL417766 | — | IC50 | = | 93.0 | nM | 7.03 |
| CHEMBL55651 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL56176 | — | IC50 | = | 367.0 | nM | 6.43 |