Assay Detail
Binding
CHEMBL812542
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Binding affinity against human Tachykinin receptor 1 expressed in astrocytoma UC11MG cells using [125I]- SP radioligand
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | UC11MG |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
A non-peptide NK1 receptor agonist showing subpicomolar affinity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 8.85 | 11.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL281797 | — | — | 1 | 11.00 |
| CHEMBL26761 | — | — | 1 | 10.96 |
| CHEMBL413027 | — | — | 1 | 10.52 |
| CHEMBL282853 | — | — | 1 | 10.12 |
| CHEMBL235363 | SUBSTANCE P | 1.0 | 1 | 9.92 |
| CHEMBL24829 | — | — | 1 | 9.66 |
| CHEMBL24999 | — | — | 1 | 8.80 |
| CHEMBL281491 | — | — | 1 | 8.51 |
| CHEMBL25521 | — | — | 1 | 8.05 |
| CHEMBL25398 | — | — | 1 | 7.96 |
| CHEMBL25639 | — | — | 1 | 7.80 |
| CHEMBL23982 | — | — | 1 | 7.77 |
| CHEMBL24136 | — | — | 1 | 7.58 |
| CHEMBL24194 | — | — | 1 | 7.28 |
| CHEMBL25065 | — | — | 1 | 6.75 |
| CHEMBL277004 | — | — | 1 | - |
| CHEMBL25058 | — | — | 1 | - |
| CHEMBL24872 | — | — | 1 | - |
| CHEMBL24135 | — | — | 1 | - |
| CHEMBL24894 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL281797 | — | IC50 | = | 0.01 | nM | 11.00 |
| CHEMBL26761 | — | IC50 | = | 0.011 | nM | 10.96 |
| CHEMBL413027 | — | IC50 | = | 0.03 | nM | 10.52 |
| CHEMBL282853 | — | IC50 | = | 0.075 | nM | 10.12 |
| CHEMBL235363 | SUBSTANCE P | IC50 | = | 0.12 | nM | 9.92 |
| CHEMBL24829 | — | IC50 | = | 0.22 | nM | 9.66 |
| CHEMBL24999 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL281491 | — | IC50 | = | 3.1 | nM | 8.51 |
| CHEMBL25521 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL25398 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL25639 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL23982 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL24136 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL24194 | — | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL25065 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL277004 | — | IC50 | = | 0.0001 | nM | - |
| CHEMBL25058 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL24872 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL24135 | — | IC50 | = | 0.0017 | nM | - |
| CHEMBL24894 | — | IC50 | > | 1000.0 | nM | - |