Assay Detail
Binding
CHEMBL812544
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Binding affinity towards Tachykinin receptor 1
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Synthesis of potent cyclic hexapeptide NK-1 antagonists. Use of a minilibrary in transforming a peptidal somatostatin receptor ligand into an NK-1 receptor ligand via a polyvalent peptidomimetic.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.99 | 7.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL420221 | — | — | 1 | 7.22 |
| CHEMBL281200 | — | — | 1 | 6.75 |
| CHEMBL282618 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL420221 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL281200 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL282618 | — | IC50 | = | 120000.0 | nM | - |