Assay Detail
Binding
CHEMBL812564
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Inhibitory activity against thymidylate synthase of Streptococcus faecium
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Lacticaseibacillus casei |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Folate analogues. 26. Syntheses and antifolate activity of 10-substituted derivatives of 5,8-dideazafolic acid and of the poly-gamma-glutamyl metabolites of N10-propargyl-5,8-dideazafolic acid (PDDF).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 8.16 | 8.33 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1160192 | — | — | 1 | 8.33 |
| CHEMBL1160188 | — | — | 1 | 8.26 |
| CHEMBL1160181 | — | — | 1 | 8.20 |
| CHEMBL1160189 | — | — | 1 | 8.00 |
| CHEMBL1160200 | — | — | 1 | 8.00 |
| CHEMBL34259 | METHOTREXATE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1160192 | — | IC50 | = | 4.7 | nM | 8.33 |
| CHEMBL1160188 | — | IC50 | = | 5.5 | nM | 8.26 |
| CHEMBL1160181 | — | IC50 | = | 6.3 | nM | 8.20 |
| CHEMBL1160189 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL1160200 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL34259 | METHOTREXATE | IC50 | = | 120000.0 | nM | - |