Assay Detail
Functional
CHEMBL812708
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In vitro cellular toxicity against chinese hamster UV4 cell line after 4 hr of compound exposure
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cricetulus griseus |
| Cell Type | UV4 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Unsymmetrical DNA cross-linking agents: combination of the CBI and PBD pharmacophores.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 7.83 | 10.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL302536 | — | — | 1 | 10.64 |
| CHEMBL302363 | — | — | 1 | 10.13 |
| CHEMBL66051 | — | — | 1 | 10.05 |
| CHEMBL432909 | — | — | 1 | 9.08 |
| CHEMBL307572 | — | — | 1 | 8.82 |
| CHEMBL70011 | — | — | 1 | 8.23 |
| CHEMBL69680 | — | — | 1 | 8.21 |
| CHEMBL307801 | — | — | 1 | 7.89 |
| CHEMBL69443 | — | — | 1 | 7.85 |
| CHEMBL305208 | — | — | 1 | 7.23 |
| CHEMBL279754 | DSB-120 | — | 1 | 7.07 |
| CHEMBL307542 | — | — | 1 | 6.80 |
| CHEMBL70019 | — | — | 1 | 6.07 |
| CHEMBL293096 | — | — | 1 | 5.82 |
| CHEMBL66736 | — | — | 1 | 5.75 |
| CHEMBL302819 | — | — | 1 | 5.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL302536 | — | IC50 | = | 0.023 | nM | 10.64 |
| CHEMBL302363 | — | IC50 | = | 0.074 | nM | 10.13 |
| CHEMBL66051 | — | IC50 | = | 0.09 | nM | 10.05 |
| CHEMBL432909 | — | IC50 | = | 0.83 | nM | 9.08 |
| CHEMBL307572 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL70011 | — | IC50 | = | 5.9 | nM | 8.23 |
| CHEMBL69680 | — | IC50 | = | 6.1 | nM | 8.21 |
| CHEMBL307801 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL69443 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL305208 | — | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL279754 | DSB-120 | IC50 | = | 86.0 | nM | 7.07 |
| CHEMBL307542 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL70019 | — | IC50 | = | 860.0 | nM | 6.07 |
| CHEMBL293096 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL66736 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL302819 | — | IC50 | = | 2500.0 | nM | 5.60 |