Assay Detail
Binding
CHEMBL812713
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Inhibitory activity against trypsin
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Design and synthesis of potent and selective 5,6-fused heterocyclic thrombin inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 6.78 | 8.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL290376 | — | — | 1 | 8.05 |
| CHEMBL422722 | — | — | 1 | 6.85 |
| CHEMBL174008 | — | — | 1 | 6.55 |
| CHEMBL175398 | — | — | 1 | 6.51 |
| CHEMBL171390 | — | — | 1 | 5.92 |
| CHEMBL173765 | — | — | 1 | - |
| CHEMBL177038 | — | — | 1 | - |
| CHEMBL173612 | — | — | 1 | - |
| CHEMBL174456 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL290376 | — | Ki | = | 9.0 | nM | 8.05 |
| CHEMBL422722 | — | Ki | = | 140.0 | nM | 6.85 |
| CHEMBL174008 | — | Ki | = | 280.0 | nM | 6.55 |
| CHEMBL175398 | — | Ki | = | 310.0 | nM | 6.51 |
| CHEMBL171390 | — | Ki | = | 1200.0 | nM | 5.92 |
| CHEMBL173765 | — | Ki | > | 15000.0 | nM | - |
| CHEMBL177038 | — | Ki | > | 15000.0 | nM | - |
| CHEMBL173612 | — | Ki | > | 6000.0 | nM | - |
| CHEMBL174456 | — | Ki | > | 15000.0 | nM | - |