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Assay Detail

CHEMBL812784

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Binding
Inhibition of MMP3
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Intermediate

Target

Stromelysin-1 (CHEMBL283)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

N-O-isopropyl sulfonamido-based hydroxamates: design, synthesis and biological evaluation of selective matrix metalloproteinase-13 inhibitors as potential therapeutic agents for osteoarthritis.
Nuti E, Casalini F, Avramova SI, Santamaria S, Cercignani G, Marinelli L, La Pietra V, Novellino E, Orlandini E, Nencetti S, Tuccinardi T, Martinelli A, Lim NH, Visse R, Nagase H, Rossello A.
J Med Chem (2009) 52 : 4757 -4773
PubMed 19606871 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 14 5.82 6.75

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL550548 1 6.75
CHEMBL550148 1 6.50
CHEMBL563679 1 6.15
CHEMBL561625 1 6.04
CHEMBL561038 1 5.92
CHEMBL561630 1 5.92
CHEMBL550081 1 5.89
CHEMBL561036 1 5.80
CHEMBL560837 1 5.75
CHEMBL550350 1 5.75
CHEMBL550628 1 5.37
CHEMBL561039 1 5.37
CHEMBL181244 1 5.23
CHEMBL563026 1 5.04

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL550548 IC50 = 180.0 nM 6.75
CHEMBL550148 IC50 = 320.0 nM 6.50
CHEMBL563679 IC50 = 710.0 nM 6.15
CHEMBL561625 IC50 = 920.0 nM 6.04
CHEMBL561038 IC50 = 1200.0 nM 5.92
CHEMBL561630 IC50 = 1200.0 nM 5.92
CHEMBL550081 IC50 = 1300.0 nM 5.89
CHEMBL561036 IC50 = 1600.0 nM 5.80
CHEMBL560837 IC50 = 1800.0 nM 5.75
CHEMBL550350 IC50 = 1800.0 nM 5.75
CHEMBL550628 IC50 = 4300.0 nM 5.37
CHEMBL561039 IC50 = 4300.0 nM 5.37
CHEMBL181244 IC50 = 5900.0 nM 5.23
CHEMBL563026 IC50 = 9100.0 nM 5.04