Assay Detail
Functional
CHEMBL812869
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Compound was tested for inhibition of 14C-Tryptophan uptake in WiDr human adenocarcinoma cells and the effect was determined at 0-100 uM concentration
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | WiDr |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
7-aminoalkyl-2-amino-1,2,3,4-tetrahydro-2-naphthoic acids as inhibitors of tryptophan uptake
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 5.48 | 6.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL8808 | — | — | 1 | 6.22 |
| CHEMBL537919 | — | — | 1 | 6.10 |
| CHEMBL8696 | — | — | 1 | 5.85 |
| CHEMBL8989 | — | — | 1 | 5.85 |
| CHEMBL9033 | — | — | 1 | 5.77 |
| CHEMBL9032 | — | — | 1 | 5.13 |
| CHEMBL544196 | — | — | 1 | 4.47 |
| CHEMBL8708 | — | — | 1 | 4.43 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL8808 | — | Ki | = | 600.0 | nM | 6.22 |
| CHEMBL537919 | — | Ki | = | 800.0 | nM | 6.10 |
| CHEMBL8696 | — | Ki | = | 1400.0 | nM | 5.85 |
| CHEMBL8989 | — | Ki | = | 1400.0 | nM | 5.85 |
| CHEMBL9033 | — | Ki | = | 1700.0 | nM | 5.77 |
| CHEMBL9032 | — | Ki | = | 7400.0 | nM | 5.13 |
| CHEMBL544196 | — | Ki | = | 34000.0 | nM | 4.47 |
| CHEMBL8708 | — | Ki | = | 37000.0 | nM | 4.43 |