Assay Detail
Functional
CHEMBL813050
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of estradiol-stimulated T-47D cell proliferation.
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | T-47D |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
(S)-(+)-4-[7-(2,2-dimethyl-1-oxopropoxy)-4-methyl-2-[4-[2-(1-piperidinyl)-ethoxy]phenyl]-2H-1-benzopyran-3-yl]-phenyl 2,2-dimethylpropanoate (EM-800): a highly potent, specific, and orally active nonsteroidal antiestrogen.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 8.86 | 9.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL308234 | — | — | 1 | 9.85 |
| CHEMBL68055 | ACOLBIFENE | 3.0 | 1 | 9.85 |
| CHEMBL291808 | — | — | 1 | 9.61 |
| CHEMBL67783 | — | — | 1 | 8.34 |
| CHEMBL67837 | — | — | 1 | 8.08 |
| CHEMBL441622 | — | — | 1 | 7.44 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL308234 | — | IC50 | = | 0.14 | nM | 9.85 |
| CHEMBL68055 | ACOLBIFENE | IC50 | = | 0.14 | nM | 9.85 |
| CHEMBL291808 | — | IC50 | = | 0.243 | nM | 9.61 |
| CHEMBL67783 | — | IC50 | = | 4.6 | nM | 8.34 |
| CHEMBL67837 | — | IC50 | = | 8.4 | nM | 8.08 |
| CHEMBL441622 | — | IC50 | = | 36.2 | nM | 7.44 |