Assay Detail
Binding
CHEMBL813069
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was tested for inhibition of V-ATPase from Chicken adrenal glands(cAG)
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Gallus gallus |
| Tissue | Adrenal gland |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
V-type proton ATPase 116 kDa subunit a 1 (CHEMBL2683) ↗| Type | SINGLE PROTEIN |
| Organism | Gallus gallus |
Publication
5-(5,6-Dichloro-2-indolyl)-2-methoxy-2,4-pentadienamides: novel and selective inhibitors of the vacuolar H+-ATPase of osteoclasts with bone antiresorptive activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.99 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL291117 | — | — | 1 | 6.70 |
| CHEMBL449696 | — | — | 1 | 6.09 |
| CHEMBL41588 | — | — | 1 | 6.03 |
| CHEMBL288419 | — | — | 1 | 5.60 |
| CHEMBL39485 | — | — | 1 | 5.55 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL291117 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL449696 | — | IC50 | = | 820.0 | nM | 6.09 |
| CHEMBL41588 | — | IC50 | = | 930.0 | nM | 6.03 |
| CHEMBL288419 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL39485 | — | IC50 | = | 2800.0 | nM | 5.55 |