Assay Detail
Binding
CHEMBL813071
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was tested for inhibition of V-ATPase from human kidney cortex(hK)
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
V-type proton ATPase subunit B, kidney isoform (CHEMBL3217) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
5-(5,6-Dichloro-2-indolyl)-2-methoxy-2,4-pentadienamides: novel and selective inhibitors of the vacuolar H+-ATPase of osteoclasts with bone antiresorptive activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.24 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL291117 | — | — | 1 | 7.00 |
| CHEMBL41588 | — | — | 1 | 6.43 |
| CHEMBL449696 | — | — | 1 | 6.36 |
| CHEMBL288419 | — | — | 1 | 5.88 |
| CHEMBL39485 | — | — | 1 | 5.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL291117 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL41588 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL449696 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL288419 | — | IC50 | = | 1320.0 | nM | 5.88 |
| CHEMBL39485 | — | IC50 | = | 3000.0 | nM | 5.52 |