Assay Detail
Binding
CHEMBL813182
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Inhibition of MMP2
19
Total Activities
15
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
N-O-isopropyl sulfonamido-based hydroxamates: design, synthesis and biological evaluation of selective matrix metalloproteinase-13 inhibitors as potential therapeutic agents for osteoarthritis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 7.72 | 8.82 |
| Ki | 5 | 8.04 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL561963 | — | — | 1 | 9.00 |
| CHEMBL550081 | — | — | 1 | 8.82 |
| CHEMBL550148 | — | — | 1 | 8.70 |
| CHEMBL560837 | — | — | 2 | 8.42 |
| CHEMBL561036 | — | — | 1 | 8.26 |
| CHEMBL550548 | — | — | 2 | 8.02 |
| CHEMBL181244 | — | — | 2 | 7.92 |
| CHEMBL561625 | — | — | 1 | 7.92 |
| CHEMBL561630 | — | — | 1 | 7.77 |
| CHEMBL550350 | — | — | 2 | 7.60 |
| CHEMBL561038 | — | — | 1 | 7.58 |
| CHEMBL561039 | — | — | 1 | 7.25 |
| CHEMBL563679 | — | — | 1 | 7.13 |
| CHEMBL563026 | — | — | 1 | 6.51 |
| CHEMBL550628 | — | — | 1 | 6.44 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL561963 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL550081 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL550148 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL560837 | — | Ki | = | 3.8 | nM | 8.42 |
| CHEMBL560837 | — | IC50 | = | 4.2 | nM | 8.38 |
| CHEMBL561036 | — | IC50 | = | 5.5 | nM | 8.26 |
| CHEMBL550548 | — | IC50 | = | 9.6 | nM | 8.02 |
| CHEMBL561625 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL181244 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL181244 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL561630 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL550350 | — | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL561038 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL550350 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL550548 | — | Ki | = | 54.0 | nM | 7.27 |
| CHEMBL561039 | — | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL563679 | — | IC50 | = | 74.0 | nM | 7.13 |
| CHEMBL563026 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL550628 | — | IC50 | = | 360.0 | nM | 6.44 |