Assay Detail

CHEMBL813326

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Binding

Scatchard analysis at concentration of the 3 uM :Apparent affinity constant (Kd) against tachykinin receptor 1

ChEMBL ↗

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Target

Substance-P receptor (CHEMBL4027) ↗

Open DB target context

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Primary target Substance-P receptor

CHEMBL4027

Anchored from Assay target.

Protein identity Substance-P receptor

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Confidence	8 — Homologous single protein target
Curated By	Autocuration

Target

Substance-P receptor (CHEMBL4027) ↗

Type	SINGLE PROTEIN
Organism	Rattus norvegicus

Publication

Imidazo[4,5-b]quinoxaline cyanines as neurokinin antagonists.

Appell KC, Babb BE, Goswami R, Hall PL, Lawrence KB, Logan ME, Przyklek-Elling R, Tomczuk BE, Venepalli BR, Yanni JM.
J Med Chem (1991) 34 : 1751 -1753
PubMed 1851847 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
Kd	2	9.13	9.74

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL278294	—	—	2	9.74

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL278294	—	Kd	=	0.18	nM	9.74
CHEMBL278294	—	Kd	=	3.0	nM	8.52