Assay Detail

CHEMBL813327

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Binding

Tested for binding affinity towards Tachykinin receptor 1 by using [3H]SP binding assay in rat brain membranes

ChEMBL ↗

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Target

Substance-P receptor (CHEMBL4027) ↗

Open DB target context

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Primary target Substance-P receptor

CHEMBL4027

Anchored from Assay target.

Protein identity Substance-P receptor

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Tissue	Brain
Subcellular	Brain membranes
Confidence	8 — Homologous single protein target
Curated By	Autocuration

Target

Substance-P receptor (CHEMBL4027) ↗

Type	SINGLE PROTEIN
Organism	Rattus norvegicus

Publication

Synthesis of RP-67,580, a new potent nonpeptide substance P antagonist

Peyronel J, Truchon A, Moutonnier C, Garret C
Bioorg Med Chem Lett (1992) 2 : 37 -40
· DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
Ki	1	8.38	8.38

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL131171	—	—	1	8.38

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL131171	—	Ki	=	4.16	nM	8.38