Assay Detail

CHEMBL813376

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Binding

Compound was tested for inhibition of squalene synthase in rat liver.

ChEMBL ↗

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Target

Squalene synthase (CHEMBL3815) ↗

Open DB target context

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Primary target Squalene synthase

CHEMBL3815

Anchored from Assay target.

Protein identity Squalene synthase

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Confidence	8 — Homologous single protein target
Curated By	Autocuration

Target

Squalene synthase (CHEMBL3815) ↗

Type	SINGLE PROTEIN
Organism	Rattus norvegicus

Publication

Diesters of zaragozic acid A: Synthesis and biological activity

Chiang YP, Biftu T, Doss GA, Plevyak SP, Marquis RW, Bergstrom JD, Kurtz MM, Rew DJ, Berger GD
Bioorg Med Chem Lett (1993) 3 : 2029 -2034
· DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
Ki	1	10.11	10.11

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL40991	ZARAGOZIC ACID A	—	1	10.11

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL40991	ZARAGOZIC ACID A	Ki	=	0.078	nM	10.11