Assay Detail
Binding
CHEMBL813380
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Tested for its inhibitory activity against rat microsomal quinuclidine squalene synthase (SQS)
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Novel optimised quinuclidine squalene synthase inhibitors
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 7.90 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL345611 | — | — | 1 | 8.70 |
| CHEMBL24362 | — | — | 1 | 8.22 |
| CHEMBL349538 | — | — | 1 | 8.10 |
| CHEMBL155574 | — | — | 1 | 7.70 |
| CHEMBL345183 | — | — | 1 | 7.70 |
| CHEMBL154472 | — | — | 1 | 7.00 |
| CHEMBL158303 | — | — | 1 | - |
| CHEMBL345742 | — | — | 1 | - |
| CHEMBL156006 | — | — | 1 | - |
| CHEMBL158304 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL345611 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL24362 | — | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL349538 | — | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL155574 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL345183 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL154472 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL158303 | — | Ki | > | 250.0 | nM | - |
| CHEMBL345742 | — | Ki | > | 250.0 | nM | - |
| CHEMBL156006 | — | Ki | > | 250.0 | nM | - |
| CHEMBL158304 | — | Ki | > | 250.0 | nM | - |