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Assay Detail

CHEMBL813591

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Binding
Inhibition of telomerase activity
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Telomerase reverse transcriptase (CHEMBL2916)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

1,4- and 2,6-disubstituted amidoanthracene-9,10-dione derivatives as inhibitors of human telomerase.
Perry PJ, Gowan SM, Reszka AP, Polucci P, Jenkins TC, Kelland LR, Neidle S.
J Med Chem (1998) 41 : 3253 -3260
PubMed 9703471 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 12 4.76 5.35

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL109382 1 5.35
CHEMBL322686 1 5.03
CHEMBL109890 1 4.96
CHEMBL323448 1 4.78
CHEMBL109617 1 4.76
CHEMBL544111 1 4.47
CHEMBL322704 1 4.46
CHEMBL544572 1 4.30
CHEMBL109388 1 -
CHEMBL111206 1 -
CHEMBL111785 1 -
CHEMBL419381 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL109382 IC50 = 4500.0 nM 5.35
CHEMBL322686 IC50 = 9400.0 nM 5.03
CHEMBL109890 IC50 = 11100.0 nM 4.96
CHEMBL323448 IC50 = 16500.0 nM 4.78
CHEMBL109617 IC50 = 17300.0 nM 4.76
CHEMBL544111 IC50 = 33500.0 nM 4.47
CHEMBL322704 IC50 = 34500.0 nM 4.46
CHEMBL544572 IC50 = 50000.0 nM 4.30
CHEMBL109388 IC50 > 50000.0 nM -
CHEMBL111206 IC50 > 50000.0 nM -
CHEMBL111785 IC50 > 50000.0 nM -
CHEMBL419381 IC50 > 50000.0 nM -