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Assay Detail

CHEMBL813799

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligand
ChEMBL ↗
49
Total Activities
49
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Cell Type CHO
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Substance-P receptor (CHEMBL249) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Structure-activity relationships of oxime neurokinin antagonists: oxime modifications.
Reichard GA, Spitler J, Aslanian R, Mutahi Mw, Shih NY, Lin L, Ting PC, Anthes JC, Piwinski JJ.
Bioorg Med Chem Lett (2002) 12 : 833 -836
PubMed 11859013 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 49 8.37 9.40

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL355041 — — 1 9.40
CHEMBL167546 — — 1 9.30
CHEMBL352588 — — 1 9.22
CHEMBL166921 — — 1 9.15
CHEMBL355429 — — 1 9.15
CHEMBL354772 — — 1 9.15
CHEMBL167606 — — 1 9.15
CHEMBL165465 — — 1 9.15
CHEMBL166961 — — 1 9.10
CHEMBL262053 — — 1 9.10
CHEMBL287369 — — 1 9.10
CHEMBL166828 — — 1 9.05
CHEMBL352813 — — 1 9.05
CHEMBL355295 — — 1 9.00
CHEMBL167994 — — 1 8.92
CHEMBL166975 — — 1 8.92
CHEMBL168272 — — 1 8.82
CHEMBL354196 — — 1 8.80
CHEMBL352364 — — 1 8.77
CHEMBL2112941 — — 1 8.77
CHEMBL352842 — — 1 8.74
CHEMBL353162 — — 1 8.72
CHEMBL263214 — — 1 8.66
CHEMBL353027 — — 1 8.66
CHEMBL354771 — — 1 8.62
CHEMBL168144 — — 1 8.55
CHEMBL166827 — — 1 8.48
CHEMBL167613 — — 1 8.33
CHEMBL66106 — — 1 8.33
CHEMBL168437 — — 1 8.15

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL355041 — Ki = 0.4 nM 9.40
CHEMBL167546 — Ki = 0.5 nM 9.30
CHEMBL352588 — Ki = 0.6 nM 9.22
CHEMBL166921 — Ki = 0.7 nM 9.15
CHEMBL355429 — Ki = 0.7 nM 9.15
CHEMBL354772 — Ki = 0.7 nM 9.15
CHEMBL167606 — Ki = 0.7 nM 9.15
CHEMBL165465 — Ki = 0.7 nM 9.15
CHEMBL166961 — Ki = 0.8 nM 9.10
CHEMBL262053 — Ki = 0.8 nM 9.10
CHEMBL287369 — Ki = 0.8 nM 9.10
CHEMBL166828 — Ki = 0.9 nM 9.05
CHEMBL352813 — Ki = 0.9 nM 9.05
CHEMBL355295 — Ki = 1.0 nM 9.00
CHEMBL166975 — Ki = 1.2 nM 8.92
CHEMBL167994 — Ki = 1.2 nM 8.92
CHEMBL168272 — Ki = 1.5 nM 8.82
CHEMBL354196 — Ki = 1.6 nM 8.80
CHEMBL352364 — Ki = 1.7 nM 8.77
CHEMBL2112941 — Ki = 1.7 nM 8.77
CHEMBL352842 — Ki = 1.8 nM 8.74
CHEMBL353162 — Ki = 1.9 nM 8.72
CHEMBL263214 — Ki = 2.2 nM 8.66
CHEMBL353027 — Ki = 2.2 nM 8.66
CHEMBL354771 — Ki = 2.4 nM 8.62
CHEMBL168144 — Ki = 2.8 nM 8.55
CHEMBL166827 — Ki = 3.3 nM 8.48
CHEMBL167613 — Ki = 4.7 nM 8.33
CHEMBL66106 — Ki = 4.7 nM 8.33
CHEMBL168437 — Ki = 7.0 nM 8.15
CHEMBL166842 — Ki = 7.4 nM 8.13
CHEMBL352614 — Ki = 8.0 nM 8.10
CHEMBL355868 — Ki = 15.0 nM 7.82
CHEMBL167409 — Ki = 15.0 nM 7.82
CHEMBL168584 — Ki = 17.0 nM 7.77
CHEMBL354091 — Ki = 17.0 nM 7.77
CHEMBL169002 — Ki = 20.0 nM 7.70
CHEMBL354892 — Ki = 24.0 nM 7.62
CHEMBL287454 — Ki = 25.0 nM 7.60
CHEMBL85980 — Ki = 25.0 nM 7.60
CHEMBL309087 — Ki = 25.0 nM 7.60
CHEMBL168769 — Ki = 25.0 nM 7.60
CHEMBL168770 — Ki = 33.0 nM 7.48
CHEMBL354822 — Ki = 38.0 nM 7.42
CHEMBL170727 — Ki = 49.0 nM 7.31
CHEMBL166759 — Ki = 57.0 nM 7.24
CHEMBL350360 — Ki = 81.0 nM 7.09
CHEMBL170325 — Ki = 100.0 nM 7.00
CHEMBL350952 — Ki = 103.0 nM 6.99