Assay Detail
Functional
CHEMBL813898
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Inhibitory activity against cultured Toxoplasma gondii
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Toxoplasma gondii |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
6-substituted 2,4-diamino-5-methylpyrido[2,3-d]pyrimidines as inhibitors of dihydrofolate reductases from Pneumocystis carinii and Toxoplasma gondii and as antitumor agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.25 | 7.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL53903 | — | — | 1 | 7.40 |
| CHEMBL23867 | — | — | 1 | 7.00 |
| CHEMBL279679 | — | — | 1 | 6.50 |
| CHEMBL23569 | — | — | 1 | 6.22 |
| CHEMBL281803 | — | — | 1 | 5.98 |
| CHEMBL23021 | — | — | 1 | 5.82 |
| CHEMBL23705 | — | — | 1 | 5.76 |
| CHEMBL50514 | — | — | 1 | 5.33 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL53903 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL23867 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL279679 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL23569 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL281803 | — | IC50 | = | 1050.0 | nM | 5.98 |
| CHEMBL23021 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL23705 | — | IC50 | = | 1730.0 | nM | 5.76 |
| CHEMBL50514 | — | IC50 | = | 4700.0 | nM | 5.33 |