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Assay Detail

CHEMBL813899

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Functional
Inhibition of Toxoplasma gondii cell growth
ChEMBL ↗
64
Total Activities
64
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Toxoplasma gondii
Confidence 1 — Organism
Curated By Expert

Target

Toxoplasma gondii (CHEMBL612888) ↗
Type ORGANISM
Organism Toxoplasma gondii

Publication

Lipophilic antifolates as agents against opportunistic infections. 1. Agents superior to trimetrexate and piritrexim against Toxoplasma gondii and Pneumocystis carinii in in vitro evaluations.
Piper JR, Johnson CA, Krauth CA, Carter RL, Hosmer CA, Queener SF, Borotz SE, Pfefferkorn ER.
J Med Chem (1996) 39 : 1271 -1280
PubMed 8632434 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 64 6.45 8.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL22623 — — 1 8.00
CHEMBL23092 — — 1 8.00
CHEMBL23383 — — 1 8.00
CHEMBL23867 — — 1 7.92
CHEMBL7492 PIRITREXIM 2.0 1 7.70
CHEMBL23220 — — 1 7.70
CHEMBL281648 — — 1 7.70
CHEMBL23713 — — 1 7.52
CHEMBL23584 — — 1 7.40
CHEMBL279705 — — 1 7.30
CHEMBL23211 — — 1 7.22
CHEMBL23569 — — 1 7.22
CHEMBL23844 — — 1 7.22
CHEMBL282948 — — 1 7.22
CHEMBL279679 — — 1 7.22
CHEMBL284544 — — 1 7.00
CHEMBL23374 — — 1 7.00
CHEMBL23416 — — 1 6.82
CHEMBL24007 — — 1 6.82
CHEMBL279680 — — 1 6.82
CHEMBL23963 — — 1 6.70
CHEMBL277217 — — 1 6.70
CHEMBL281803 — — 1 6.70
CHEMBL23076 — — 1 6.70
CHEMBL23227 — — 1 6.70
CHEMBL279983 — — 1 6.70
CHEMBL291239 — — 1 6.70
CHEMBL23021 — — 1 6.70
CHEMBL23272 — — 1 6.70
CHEMBL26006 — — 1 6.60

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL22623 — IC50 = 10.0 nM 8.00
CHEMBL23383 — IC50 = 10.0 nM 8.00
CHEMBL23092 — IC50 = 10.0 nM 8.00
CHEMBL23867 — IC50 = 12.0 nM 7.92
CHEMBL7492 PIRITREXIM IC50 = 20.0 nM 7.70
CHEMBL23220 — IC50 = 20.0 nM 7.70
CHEMBL281648 — IC50 = 20.0 nM 7.70
CHEMBL23713 — IC50 = 30.0 nM 7.52
CHEMBL23584 — IC50 = 40.0 nM 7.40
CHEMBL279705 — IC50 = 50.0 nM 7.30
CHEMBL282948 — IC50 = 60.0 nM 7.22
CHEMBL279679 — IC50 = 60.0 nM 7.22
CHEMBL23844 — IC50 = 60.0 nM 7.22
CHEMBL23569 — IC50 = 60.0 nM 7.22
CHEMBL23211 — IC50 = 60.0 nM 7.22
CHEMBL284544 — IC50 = 100.0 nM 7.00
CHEMBL23374 — IC50 = 100.0 nM 7.00
CHEMBL23416 — IC50 = 150.0 nM 6.82
CHEMBL24007 — IC50 = 150.0 nM 6.82
CHEMBL279680 — IC50 = 150.0 nM 6.82
CHEMBL23272 — IC50 = 200.0 nM 6.70
CHEMBL23021 — IC50 = 200.0 nM 6.70
CHEMBL291239 — IC50 = 200.0 nM 6.70
CHEMBL279983 — IC50 = 200.0 nM 6.70
CHEMBL23076 — IC50 = 200.0 nM 6.70
CHEMBL281803 — IC50 = 200.0 nM 6.70
CHEMBL277217 — IC50 = 200.0 nM 6.70
CHEMBL23963 — IC50 = 200.0 nM 6.70
CHEMBL23227 — IC50 = 200.0 nM 6.70
CHEMBL26006 — IC50 = 250.0 nM 6.60
CHEMBL22677 — IC50 = 300.0 nM 6.52
CHEMBL23705 — IC50 = 300.0 nM 6.52
CHEMBL281131 — IC50 = 300.0 nM 6.52
CHEMBL24344 — IC50 = 300.0 nM 6.52
CHEMBL23911 — IC50 = 300.0 nM 6.52
CHEMBL36 PYRIMETHAMINE IC50 = 400.0 nM 6.40
CHEMBL23454 — IC50 = 600.0 nM 6.22
CHEMBL283518 — IC50 = 600.0 nM 6.22
CHEMBL23382 — IC50 = 600.0 nM 6.22
CHEMBL22672 — IC50 = 700.0 nM 6.16
CHEMBL22924 — IC50 = 800.0 nM 6.10
CHEMBL23532 — IC50 = 1000.0 nM 6.00
CHEMBL23560 — IC50 = 1000.0 nM 6.00
CHEMBL23466 — IC50 = 1000.0 nM 6.00
CHEMBL23919 — IC50 = 1000.0 nM 6.00
CHEMBL276954 — IC50 = 1000.0 nM 6.00
CHEMBL22543 — IC50 = 1600.0 nM 5.80
CHEMBL23495 — IC50 = 2000.0 nM 5.70
CHEMBL22434 — IC50 = 3000.0 nM 5.52
CHEMBL23146 — IC50 = 3000.0 nM 5.52