Assay Detail
Binding
CHEMBL813938
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Binding affinity towards Tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligand
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
The design and synthesis of novel NK1/NK2 dual antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 8.04 | 9.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL306311 | — | — | 1 | 9.15 |
| CHEMBL56038 | — | — | 1 | 9.05 |
| CHEMBL407749 | — | — | 1 | 8.40 |
| CHEMBL430416 | — | — | 1 | 8.30 |
| CHEMBL405129 | — | — | 1 | 8.05 |
| CHEMBL72930 | — | — | 1 | 7.70 |
| CHEMBL293432 | — | — | 1 | 7.62 |
| CHEMBL287454 | — | — | 1 | 7.60 |
| CHEMBL309087 | — | — | 1 | 7.60 |
| CHEMBL311387 | — | — | 1 | 7.48 |
| CHEMBL76334 | — | — | 1 | 7.47 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL306311 | — | Ki | = | 0.7 | nM | 9.15 |
| CHEMBL56038 | — | Ki | = | 0.9 | nM | 9.05 |
| CHEMBL407749 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL430416 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL405129 | — | Ki | = | 9.0 | nM | 8.05 |
| CHEMBL72930 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL293432 | — | Ki | = | 24.0 | nM | 7.62 |
| CHEMBL287454 | — | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL309087 | — | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL311387 | — | Ki | = | 33.0 | nM | 7.48 |
| CHEMBL76334 | — | Ki | = | 34.0 | nM | 7.47 |