Assay Detail
Binding
CHEMBL814034
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Compound was tested for inhibition of squalene synthase from rat liver microsomes using [3H]farnesyl pyrophosphate (FPP) as substrate
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Liver |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Cyclopentanedi- and tricarboxylic acids as squalene synthase inhibitors: syntheses and evaluation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.39 | 7.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL40991 | ZARAGOZIC ACID A | — | 1 | 7.92 |
| CHEMBL445618 | — | — | 1 | 7.43 |
| CHEMBL355009 | — | — | 1 | 6.77 |
| CHEMBL170032 | — | — | 1 | 6.62 |
| CHEMBL355158 | — | — | 1 | 6.24 |
| CHEMBL354568 | — | — | 1 | 5.54 |
| CHEMBL352367 | — | — | 1 | 5.52 |
| CHEMBL355385 | — | — | 1 | 5.04 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL40991 | ZARAGOZIC ACID A | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL445618 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL355009 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL170032 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL355158 | — | IC50 | = | 580.0 | nM | 6.24 |
| CHEMBL354568 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL352367 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL355385 | — | IC50 | = | 9100.0 | nM | 5.04 |