Assay Detail
Functional
CHEMBL814137
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Compound was tested for inhibition of thermolysine, a bacterial zinc-endopeptidase
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Design and synthesis of a new class of conformationally constrained inhibitors to probe the active sites of thermolysine and neutral endopeptidase 24.11
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.27 | 5.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL298827 | (S)-THIORPHAN | — | 1 | 5.75 |
| CHEMBL61512 | (R)-THIORPHAN | — | 1 | 5.52 |
| CHEMBL63704 | — | — | 1 | 4.54 |
| CHEMBL67069 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL298827 | (S)-THIORPHAN | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL61512 | (R)-THIORPHAN | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL63704 | — | IC50 | = | 29000.0 | nM | 4.54 |
| CHEMBL67069 | — | IC50 | = | 110000.0 | nM | - |