Assay Detail
Binding
CHEMBL814153
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Inhibitory activity against HSV-1 thymidine kinase isolated from HeLa cells
36
Total Activities
36
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | HeLa |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Thymidine kinase (CHEMBL1820) ↗| Type | SINGLE PROTEIN |
| Organism | Human herpesvirus 1 (strain SC16) (HHV-1) (Human herpes simplex virus1) |
Publication
Quantitative structure-activity relationships of N2-phenylguanines as inhibitors of herpes simplex virus thymidine kinases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 36 | 5.07 | 6.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL405761 | — | — | 1 | 6.82 |
| CHEMBL102001 | — | — | 1 | 6.10 |
| CHEMBL53835 | — | — | 1 | 6.00 |
| CHEMBL103645 | — | — | 1 | 6.00 |
| CHEMBL103810 | — | — | 1 | 5.96 |
| CHEMBL101020 | — | — | 1 | 5.85 |
| CHEMBL406300 | — | — | 1 | 5.82 |
| CHEMBL52562 | — | — | 1 | 5.82 |
| CHEMBL35886 | — | — | 1 | 5.60 |
| CHEMBL65438 | — | — | 1 | 5.52 |
| CHEMBL63910 | — | — | 1 | 5.48 |
| CHEMBL406058 | — | — | 1 | 5.30 |
| CHEMBL16026 | — | — | 1 | 5.16 |
| CHEMBL287727 | — | — | 1 | 5.10 |
| CHEMBL296595 | — | — | 1 | 5.10 |
| CHEMBL63463 | — | — | 1 | 4.92 |
| CHEMBL15985 | — | — | 1 | 4.82 |
| CHEMBL318027 | — | — | 1 | 4.70 |
| CHEMBL65197 | — | — | 1 | 4.70 |
| CHEMBL293668 | — | — | 1 | 4.60 |
| CHEMBL101651 | — | — | 1 | 4.52 |
| CHEMBL64473 | — | — | 1 | 4.52 |
| CHEMBL101730 | — | — | 1 | 4.52 |
| CHEMBL420269 | — | — | 1 | 4.40 |
| CHEMBL319254 | — | — | 1 | 4.40 |
| CHEMBL63439 | — | — | 1 | 4.40 |
| CHEMBL299415 | — | — | 1 | 4.30 |
| CHEMBL16193 | — | — | 1 | 4.30 |
| CHEMBL36877 | — | — | 1 | 4.30 |
| CHEMBL101143 | — | — | 1 | 4.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL405761 | — | IC50 | = | 151.36 | nM | 6.82 |
| CHEMBL102001 | — | IC50 | = | 794.33 | nM | 6.10 |
| CHEMBL53835 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL103645 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL103810 | — | IC50 | = | 1096.48 | nM | 5.96 |
| CHEMBL101020 | — | IC50 | = | 1412.54 | nM | 5.85 |
| CHEMBL406300 | — | IC50 | = | 1513.56 | nM | 5.82 |
| CHEMBL52562 | — | IC50 | = | 1513.56 | nM | 5.82 |
| CHEMBL35886 | — | IC50 | = | 2511.89 | nM | 5.60 |
| CHEMBL65438 | — | IC50 | = | 3019.95 | nM | 5.52 |
| CHEMBL63910 | — | IC50 | = | 3311.31 | nM | 5.48 |
| CHEMBL406058 | — | IC50 | = | 5011.87 | nM | 5.30 |
| CHEMBL16026 | — | IC50 | = | 6918.31 | nM | 5.16 |
| CHEMBL287727 | — | IC50 | = | 7943.28 | nM | 5.10 |
| CHEMBL296595 | — | IC50 | = | 7943.28 | nM | 5.10 |
| CHEMBL63463 | — | IC50 | = | 12022.64 | nM | 4.92 |
| CHEMBL15985 | — | IC50 | = | 15135.61 | nM | 4.82 |
| CHEMBL65197 | — | IC50 | = | 19952.62 | nM | 4.70 |
| CHEMBL318027 | — | IC50 | = | 19952.62 | nM | 4.70 |
| CHEMBL293668 | — | IC50 | = | 25118.86 | nM | 4.60 |
| CHEMBL101651 | — | IC50 | = | 30199.52 | nM | 4.52 |
| CHEMBL64473 | — | IC50 | = | 30199.52 | nM | 4.52 |
| CHEMBL101730 | — | IC50 | = | 30199.52 | nM | 4.52 |
| CHEMBL420269 | — | IC50 | = | 39810.72 | nM | 4.40 |
| CHEMBL319254 | — | IC50 | = | 39810.72 | nM | 4.40 |
| CHEMBL63439 | — | IC50 | = | 39810.72 | nM | 4.40 |
| CHEMBL16193 | — | IC50 | = | 50118.72 | nM | 4.30 |
| CHEMBL36877 | — | IC50 | = | 50118.72 | nM | 4.30 |
| CHEMBL299415 | — | IC50 | = | 50118.72 | nM | 4.30 |
| CHEMBL101143 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL51613 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL99634 | — | IC50 | = | 269153.48 | nM | - |
| CHEMBL53890 | — | IC50 | = | 141253.75 | nM | - |
| CHEMBL298986 | — | IC50 | = | 301995.17 | nM | - |
| CHEMBL327494 | — | IC50 | = | 501187.23 | nM | - |
| CHEMBL103978 | — | IC50 | = | 199526.23 | nM | - |