Assay Detail
Binding
CHEMBL814213
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In vitro inhibitory activity against Squalene Synthase
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
(1 alpha, 2 beta, 3 beta, 4 alpha)-1,2-bis[N-propyl-N-(4-phenoxybenzyl) amino]carbonyl]cyclobutane-3,4-dicarboxylic acid (A-87049): a novel potent squalene synthase inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 6.28 | 7.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL303461 | — | — | 1 | 7.89 |
| CHEMBL304119 | — | — | 1 | 7.85 |
| CHEMBL445618 | — | — | 1 | 7.43 |
| CHEMBL303235 | — | — | 1 | 6.89 |
| CHEMBL68289 | — | — | 1 | 6.85 |
| CHEMBL306441 | — | — | 1 | 6.75 |
| CHEMBL304850 | — | — | 1 | 6.14 |
| CHEMBL302702 | — | — | 1 | 5.85 |
| CHEMBL68005 | — | — | 1 | 5.85 |
| CHEMBL67051 | — | — | 1 | 5.10 |
| CHEMBL67614 | — | — | 1 | 5.10 |
| CHEMBL305004 | — | — | 1 | 5.00 |
| CHEMBL302010 | — | — | 1 | 5.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL303461 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL304119 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL445618 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL303235 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL68289 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL306441 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL304850 | — | IC50 | = | 720.0 | nM | 6.14 |
| CHEMBL302702 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL68005 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL67051 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL67614 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL305004 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL302010 | — | IC50 | = | 10000.0 | nM | 5.00 |