Assay Detail
Binding
CHEMBL814227
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Inhibitory activity against human prostatic Steroid 5-alpha-reductase
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
3-oxo-5-alpha-steroid 4-dehydrogenase 2 (CHEMBL1856) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Inhibition of steroid 5-reductase by inverted, competitive inhibitors
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.35 | 8.07 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2298601 | — | — | 1 | 8.07 |
| CHEMBL352942 | — | — | 1 | 5.40 |
| CHEMBL353524 | — | — | 1 | 4.92 |
| CHEMBL352434 | — | — | 1 | 4.82 |
| CHEMBL355567 | — | — | 1 | 4.50 |
| CHEMBL169621 | — | — | 1 | 4.40 |
| CHEMBL166881 | — | — | 1 | - |
| CHEMBL2311174 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2298601 | — | IC50 | = | 8.6 | nM | 8.07 |
| CHEMBL352942 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL353524 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL352434 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL355567 | — | IC50 | = | 32000.0 | nM | 4.50 |
| CHEMBL169621 | — | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL166881 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2311174 | — | IC50 | > | 430.0 | nM | - |