Assay Detail
Binding
CHEMBL814434
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Tested for inhibition of thromboxane synthetase from spontaneously hypertensive rats
52
Total Activities
52
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Thromboxane synthetase inhibitors and antihypertensive agents. 4. N-[(1H-imidazol-1-yl)alkyl] derivatives of quinazoline-2,4(1H,3H)-diones, quinazolin-4(3H)-ones, and 1,2,3-benzotriazin-4(3H)-ones.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 52 | 7.06 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL309960 | — | — | 1 | 8.70 |
| CHEMBL75787 | — | — | 1 | 8.70 |
| CHEMBL76234 | — | — | 1 | 8.52 |
| CHEMBL420931 | — | — | 1 | 8.52 |
| CHEMBL72450 | — | — | 1 | 8.40 |
| CHEMBL72684 | — | — | 1 | 8.15 |
| CHEMBL541827 | — | — | 1 | 8.15 |
| CHEMBL74733 | — | — | 1 | 8.10 |
| CHEMBL76341 | — | — | 1 | 8.05 |
| CHEMBL74627 | — | — | 1 | 8.00 |
| CHEMBL554990 | — | — | 1 | 8.00 |
| CHEMBL307631 | — | — | 1 | 8.00 |
| CHEMBL73143 | — | — | 1 | 7.92 |
| CHEMBL307725 | — | — | 1 | 7.70 |
| CHEMBL75451 | — | — | 1 | 7.52 |
| CHEMBL73065 | — | — | 1 | 7.52 |
| CHEMBL73620 | — | — | 1 | 7.52 |
| CHEMBL73236 | — | — | 1 | 7.40 |
| CHEMBL73426 | — | — | 1 | 7.40 |
| CHEMBL73158 | — | — | 1 | 7.40 |
| CHEMBL72382 | — | — | 1 | 7.30 |
| CHEMBL1743616 | — | — | 1 | 7.30 |
| CHEMBL75609 | — | — | 1 | 7.30 |
| CHEMBL1743613 | — | — | 1 | 7.22 |
| CHEMBL73769 | — | — | 1 | 7.16 |
| CHEMBL73748 | — | — | 1 | 7.05 |
| CHEMBL311689 | — | — | 1 | 7.05 |
| CHEMBL310904 | — | — | 1 | 7.00 |
| CHEMBL75449 | — | — | 1 | 6.82 |
| CHEMBL267473 | DAZOXIBEN | 2.0 | 1 | 6.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL309960 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL75787 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL420931 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL76234 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL72450 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL72684 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL541827 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL74733 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL76341 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL74627 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL554990 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL307631 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL73143 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL307725 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL73620 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL73065 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL75451 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL73236 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL73426 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL73158 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL72382 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL1743616 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL75609 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL1743613 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL73769 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL73748 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL311689 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL310904 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL75449 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL267473 | DAZOXIBEN | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL74973 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL310955 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL307382 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL73407 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL75249 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL74915 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL75252 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL312536 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL74207 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL74821 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL72070 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL75334 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL73779 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL72690 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL74516 | — | IC50 | = | 820.0 | nM | 6.09 |
| CHEMBL1743611 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL75344 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL74693 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL72273 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL73850 | — | IC50 | = | 1700.0 | nM | 5.77 |