Assay Detail
Binding
CHEMBL814600
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Effect on CHO-K1 cells stably transfected with Thyroid hormone receptor beta and an alkaline phosphate reporter gene downstream thyroid response element TRAF-beta1 was determined
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO-K1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Thyroid receptor ligands. 1. Agonist ligands selective for the thyroid receptor beta1.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 8.63 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL39174 | — | — | 1 | 9.70 |
| CHEMBL418432 | — | — | 1 | 9.55 |
| CHEMBL41036 | — | — | 1 | 8.46 |
| CHEMBL40738 | — | — | 1 | 6.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL39174 | — | EC50 | = | 0.2 | nM | 9.70 |
| CHEMBL418432 | — | EC50 | = | 0.28 | nM | 9.55 |
| CHEMBL41036 | — | EC50 | = | 3.5 | nM | 8.46 |
| CHEMBL40738 | — | EC50 | = | 150.0 | nM | 6.82 |