Assay Detail
Binding
CHEMBL814601
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Concentration required to inhibit 50% of I-T3 binding to hTR1 (Thyroid hormone receptor beta) was determined
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Thyroid receptor ligands. 1. Agonist ligands selective for the thyroid receptor beta1.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 9.64 | 10.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL291053 | THYROPROPIC ACID | 2.0 | 1 | 10.72 |
| CHEMBL289343 | — | — | 1 | 10.60 |
| CHEMBL41632 | TIRATRICOL | 3.0 | 1 | 10.32 |
| CHEMBL39174 | — | — | 1 | 10.02 |
| CHEMBL41314 | — | — | 1 | 9.96 |
| CHEMBL418432 | — | — | 1 | 9.82 |
| CHEMBL557 | DETROTHYRONINE | 2.0 | 1 | 9.59 |
| CHEMBL41036 | — | — | 1 | 8.96 |
| CHEMBL289965 | — | — | 1 | 8.68 |
| CHEMBL40738 | — | — | 1 | 7.68 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL291053 | THYROPROPIC ACID | IC50 | = | 0.019 | nM | 10.72 |
| CHEMBL289343 | — | IC50 | = | 0.025 | nM | 10.60 |
| CHEMBL41632 | TIRATRICOL | IC50 | = | 0.048 | nM | 10.32 |
| CHEMBL39174 | — | IC50 | = | 0.095 | nM | 10.02 |
| CHEMBL41314 | — | IC50 | = | 0.11 | nM | 9.96 |
| CHEMBL418432 | — | IC50 | = | 0.15 | nM | 9.82 |
| CHEMBL557 | DETROTHYRONINE | IC50 | = | 0.26 | nM | 9.59 |
| CHEMBL41036 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL289965 | — | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL40738 | — | IC50 | = | 21.0 | nM | 7.68 |