Assay Detail
Functional
CHEMBL814645
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In vitro cytotoxicity against man colon carcinoma line WiDr cell lines transfected with Escherichia coli B nitroreductase (NTR)
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | WiDr |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Nitrobenzyl carbamate prodrugs of enediynes for nitroreductase gene-directed enzyme prodrug therapy (GDEPT).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.41 | 5.74 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL116759 | — | — | 1 | 5.74 |
| CHEMBL432797 | — | — | 1 | 5.08 |
| CHEMBL325046 | — | — | 1 | - |
| CHEMBL23330 | TRETAZICAR | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL116759 | — | IC50 | = | 1810.0 | nM | 5.74 |
| CHEMBL432797 | — | IC50 | = | 8400.0 | nM | 5.08 |
| CHEMBL325046 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL23330 | TRETAZICAR | IC50 | = | 565400.0 | nM | - |