Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL814653

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
In vitro inhibition of Lactobacillus casei Thymidylate synthase.
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Thymidylate synthase (CHEMBL2555)
Type SINGLE PROTEIN
Organism Escherichia coli K-12

Publication

Phthalein derivatives as a new tool for selectivity in thymidylate synthase inhibition.
Costi PM, Rinaldi M, Tondi D, Pecorari P, Barlocco D, Ghelli S, Stroud RM, Santi DV, Stout TJ, Musiu C, Marangiu EM, Pani A, Congiu D, Loi GA, La Colla P.
J Med Chem (1999) 42 : 2112 -2124
PubMed 10377217 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 20 5.80 7.02

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL422395 1 7.02
CHEMBL308223 1 6.60
CHEMBL67116 1 6.16
CHEMBL293670 1 6.16
CHEMBL294280 1 6.14
CHEMBL303950 1 6.00
CHEMBL67851 1 5.82
CHEMBL302555 1 5.82
CHEMBL63528 1 5.82
CHEMBL308680 1 5.82
CHEMBL303171 1 5.80
CHEMBL68299 1 5.77
CHEMBL308417 1 5.72
CHEMBL67836 1 5.55
CHEMBL63857 PHENOLPHTHALEIN 4.0 1 5.33
CHEMBL65398 1 5.20
CHEMBL66405 1 5.16
CHEMBL69792 1 4.58
CHEMBL305207 1 -
CHEMBL66576 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL422395 Ki = 95.0 nM 7.02
CHEMBL308223 Ki = 250.0 nM 6.60
CHEMBL67116 Ki = 700.0 nM 6.16
CHEMBL293670 Ki = 700.0 nM 6.16
CHEMBL294280 Ki = 730.0 nM 6.14
CHEMBL303950 Ki = 1000.0 nM 6.00
CHEMBL67851 Ki = 1500.0 nM 5.82
CHEMBL302555 Ki = 1500.0 nM 5.82
CHEMBL63528 Ki = 1500.0 nM 5.82
CHEMBL308680 Ki = 1500.0 nM 5.82
CHEMBL303171 Ki = 1600.0 nM 5.80
CHEMBL68299 Ki = 1700.0 nM 5.77
CHEMBL308417 Ki = 1900.0 nM 5.72
CHEMBL67836 Ki = 2800.0 nM 5.55
CHEMBL63857 PHENOLPHTHALEIN Ki = 4700.0 nM 5.33
CHEMBL65398 Ki = 6300.0 nM 5.20
CHEMBL66405 Ki = 7000.0 nM 5.16
CHEMBL69792 Ki = 26000.0 nM 4.58
CHEMBL305207 Ki = 104700.0 nM -
CHEMBL66576 Ki = 295600.0 nM -