Assay Detail
Binding
CHEMBL814665
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Inhibitory activity against Tachykinin receptor 1 in mouse brain using [125I]-labeled Boltan-Hunter substance P as radioligand
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Brain |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
3-Aryl-1,2-diacetamidopropane derivatives as novel and potent NK-1 receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.88 | 8.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL348976 | — | — | 1 | 8.89 |
| CHEMBL131171 | — | — | 1 | 8.06 |
| CHEMBL350151 | — | — | 1 | 6.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL348976 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL131171 | — | IC50 | = | 8.7 | nM | 8.06 |
| CHEMBL350151 | — | IC50 | = | 200.0 | nM | 6.70 |