Assay Detail
Functional
CHEMBL814716
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of neurokinin A induced contraction of rabbit pulmonary artery (RPA) tissue expressing Tachykinin receptor 2
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Oryctolagus cuniculus |
| Tissue | Artery |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
3-Aryl-1,2-diacetamidopropane derivatives as novel and potent NK-1 receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 4 | 4.60 | 4.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL352102 | — | — | 1 | 4.70 |
| CHEMBL351236 | — | — | 1 | 4.70 |
| CHEMBL42407 | LANEPITANT | 2.0 | 1 | 4.70 |
| CHEMBL16192 | CP-96345 | — | 1 | 4.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL352102 | — | Kd | = | 19952.62 | nM | 4.70 |
| CHEMBL351236 | — | Kd | = | 19952.62 | nM | 4.70 |
| CHEMBL42407 | LANEPITANT | Kd | = | 19952.62 | nM | 4.70 |
| CHEMBL16192 | CP-96345 | Kd | = | 50118.72 | nM | 4.30 |