Assay Detail
Functional
CHEMBL814979
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory activity against Streptococcus faecium ATCC 8043
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Enterococcus faecium |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Folate analogues. 26. Syntheses and antifolate activity of 10-substituted derivatives of 5,8-dideazafolic acid and of the poly-gamma-glutamyl metabolites of N10-propargyl-5,8-dideazafolic acid (PDDF).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 8.60 | 9.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1160200 | — | — | 1 | 9.89 |
| CHEMBL34259 | METHOTREXATE | 4.0 | 1 | 9.52 |
| CHEMBL1160189 | — | — | 1 | 9.44 |
| CHEMBL49651 | — | — | 1 | 8.59 |
| CHEMBL48619 | — | — | 1 | 8.17 |
| CHEMBL1160188 | — | — | 1 | 7.47 |
| CHEMBL1160192 | — | — | 1 | 7.12 |
| CHEMBL1160181 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1160200 | — | IC50 | = | 0.13 | nM | 9.89 |
| CHEMBL34259 | METHOTREXATE | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL1160189 | — | IC50 | = | 0.36 | nM | 9.44 |
| CHEMBL49651 | — | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL48619 | — | IC50 | = | 6.7 | nM | 8.17 |
| CHEMBL1160188 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL1160192 | — | IC50 | = | 75.0 | nM | 7.12 |
| CHEMBL1160181 | — | IC50 | > | 80.0 | nM | - |