Assay Detail
Functional
CHEMBL814980
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Inhibitory activity against Streptococcus faecium MTX-resistant
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Enterococcus faecium |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Folate analogues. 26. Syntheses and antifolate activity of 10-substituted derivatives of 5,8-dideazafolic acid and of the poly-gamma-glutamyl metabolites of N10-propargyl-5,8-dideazafolic acid (PDDF).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.33 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1160200 | — | — | 1 | 7.70 |
| CHEMBL1160189 | — | — | 1 | 6.90 |
| CHEMBL49651 | — | — | 1 | 5.82 |
| CHEMBL48619 | — | — | 1 | 5.80 |
| CHEMBL34259 | METHOTREXATE | 4.0 | 1 | 5.41 |
| CHEMBL1160181 | — | — | 1 | - |
| CHEMBL1160188 | — | — | 1 | - |
| CHEMBL1160192 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1160200 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL1160189 | — | IC50 | = | 125.0 | nM | 6.90 |
| CHEMBL49651 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL48619 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL34259 | METHOTREXATE | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL1160181 | — | IC50 | > | 800.0 | nM | - |
| CHEMBL1160188 | — | IC50 | > | 800.0 | nM | - |
| CHEMBL1160192 | — | IC50 | > | 800.0 | nM | - |