Assay Detail
Functional
CHEMBL815032
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Inhibition of tubulin polymerization using bovine brain tubulin
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Bos taurus |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of myoseverin derivatives: microtubule assembly inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 5.12 | 5.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL141477 | — | — | 1 | 5.70 |
| CHEMBL336919 | — | — | 1 | 5.52 |
| CHEMBL136246 | — | — | 1 | 5.52 |
| CHEMBL138292 | — | — | 1 | 5.30 |
| CHEMBL139200 | — | — | 1 | 5.30 |
| CHEMBL139282 | — | — | 1 | 5.30 |
| CHEMBL141689 | MYOSEVERIN | — | 1 | 5.10 |
| CHEMBL140649 | — | — | 1 | 4.60 |
| CHEMBL140654 | — | — | 1 | 4.60 |
| CHEMBL343349 | — | — | 1 | 4.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL141477 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL336919 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL136246 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL138292 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL139200 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL139282 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL141689 | MYOSEVERIN | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL140649 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL140654 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL343349 | — | IC50 | = | 50000.0 | nM | 4.30 |