Assay Detail
Functional
CHEMBL815033
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of tubulin polymerization with preincubation for 15 minutes at 37 degree Centigrade prior to addition of the GTP required for polymerization
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Bos taurus |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Antitumor agents. 139. Synthesis and biological evaluation of thiocolchicine analogs 5,6-dihydro-6(S)-(acyloxy)- and 5,6-dihydro-6(S)-[(aroyloxy)methyl]-1,2,3-trimethoxy-9-(methylthio)-8H- cyclohepta[a]naphthalen-8-ones as novel cytotoxic and antimitotic agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 5.46 | 5.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL18981 | THIOCOLCHICINE | — | 1 | 5.68 |
| CHEMBL153629 | — | — | 1 | 5.62 |
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 5.54 |
| CHEMBL291198 | — | — | 1 | 5.52 |
| CHEMBL346889 | — | — | 1 | 5.47 |
| CHEMBL150672 | — | — | 1 | 5.47 |
| CHEMBL3085279 | — | — | 1 | 5.44 |
| CHEMBL357350 | — | — | 1 | 5.43 |
| CHEMBL107 | COLCHICINE | 4.0 | 1 | 5.38 |
| CHEMBL153743 | — | — | 1 | 5.35 |
| CHEMBL153593 | — | — | 1 | 5.18 |
| CHEMBL149532 | — | — | 1 | - |
| CHEMBL52536 | — | — | 1 | - |
| CHEMBL51766 | — | — | 1 | - |
| CHEMBL150611 | — | — | 1 | - |
| CHEMBL431151 | — | — | 1 | - |
| CHEMBL346395 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL18981 | THIOCOLCHICINE | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL153629 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL291198 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL346889 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL150672 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL3085279 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL357350 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL107 | COLCHICINE | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL153743 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL153593 | — | IC50 | = | 6600.0 | nM | 5.18 |
| CHEMBL149532 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL52536 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL51766 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL150611 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL431151 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL346395 | — | IC50 | > | 40000.0 | nM | - |