Assay Detail
Functional
CHEMBL815124
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Ability to mobilize Ca+2 in LTD4 dependent Ca+2 mobilization assay in differentiated human monocytic U-937 cells
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | U-937 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
N-carbamoyl analogs of Zafirlukast: potent receptor antagonists of leukotriene D4.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 9.31 | 10.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL79741 | — | — | 1 | 10.00 |
| CHEMBL79479 | — | — | 1 | 10.00 |
| CHEMBL79952 | — | — | 1 | 9.70 |
| CHEMBL311868 | — | — | 1 | 9.52 |
| CHEMBL313567 | — | — | 1 | 9.40 |
| CHEMBL78140 | — | — | 1 | 9.40 |
| CHEMBL78141 | — | — | 1 | 9.22 |
| CHEMBL310446 | — | — | 1 | 9.10 |
| CHEMBL603 | ZAFIRLUKAST | 4.0 | 1 | 9.00 |
| CHEMBL79366 | — | — | 1 | 9.00 |
| CHEMBL1048 | N-DEALKYLATED DERIVATIVE | — | 1 | 8.70 |
| CHEMBL83166 | — | — | 1 | 8.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL79741 | — | IC50 | = | 0.1 | nM | 10.00 |
| CHEMBL79479 | — | IC50 | = | 0.1 | nM | 10.00 |
| CHEMBL79952 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL311868 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL313567 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL78140 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL78141 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL310446 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL603 | ZAFIRLUKAST | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL79366 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL1048 | N-DEALKYLATED DERIVATIVE | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL83166 | — | IC50 | = | 2.0 | nM | 8.70 |