Assay Detail
Binding
CHEMBL815212
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory activity against human recombinant arginine vasopressin V2 receptor using [3H]AVP as radioligand in CHO cells
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CHO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Synthesis and structure-activity relationships of 5,6,7,8-tetrahydro-4H-thieno[3,2-b]azepine derivatives: novel arginine vasopressin antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 7.70 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL368354 | — | — | 1 | 9.00 |
| CHEMBL369832 | — | — | 1 | 8.70 |
| CHEMBL413748 | — | — | 1 | 8.22 |
| CHEMBL177885 | — | — | 1 | 8.10 |
| CHEMBL367323 | — | — | 1 | 8.05 |
| CHEMBL368818 | — | — | 1 | 8.00 |
| CHEMBL175212 | — | — | 1 | 7.70 |
| CHEMBL430083 | — | — | 1 | 7.70 |
| CHEMBL368353 | — | — | 1 | 7.52 |
| CHEMBL177285 | — | — | 1 | 7.30 |
| CHEMBL175182 | — | — | 1 | 7.22 |
| CHEMBL177248 | — | — | 1 | 7.10 |
| CHEMBL435331 | — | — | 1 | 7.10 |
| CHEMBL366790 | — | — | 1 | 7.10 |
| CHEMBL176146 | — | — | 1 | 6.70 |
| CHEMBL369150 | — | — | 1 | - |
| CHEMBL366816 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL368354 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL369832 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL413748 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL177885 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL367323 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL368818 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL175212 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL430083 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL368353 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL177285 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL175182 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL177248 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL435331 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL366790 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL176146 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL369150 | — | IC50 | < | 10.0 | nM | - |
| CHEMBL366816 | — | IC50 | > | 10000.0 | nM | - |