Assay Detail
Binding
CHEMBL815213
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Inhibitory activity against human recombinant arginine vasopressin V2 receptor using [3H]AVP as radioligand in CHO cells
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
New analgesic drugs derived from phencyclidine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 7.36 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL175813 | — | — | 1 | 8.30 |
| CHEMBL368791 | — | — | 1 | 7.52 |
| CHEMBL175930 | — | — | 1 | 7.52 |
| CHEMBL177556 | — | — | 1 | 7.30 |
| CHEMBL176264 | — | — | 1 | 7.22 |
| CHEMBL420762 | MOZAVAPTAN | 4.0 | 1 | 6.30 |
| CHEMBL369712 | — | — | 1 | - |
| CHEMBL175211 | — | — | 1 | - |
| CHEMBL368462 | — | — | 1 | - |
| CHEMBL441498 | — | — | 1 | - |
| CHEMBL175411 | — | — | 1 | - |
| CHEMBL360272 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL175813 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL368791 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL175930 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL177556 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL176264 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL420762 | MOZAVAPTAN | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL369712 | — | IC50 | < | 10.0 | nM | - |
| CHEMBL175211 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL368462 | — | IC50 | < | 10.0 | nM | - |
| CHEMBL441498 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL175411 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL360272 | — | IC50 | > | 10000.0 | nM | - |